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    Advanced Science∣Mitochondrial Protein IFI27 Promotes the Thermogenic Mechanism in Adipocytes

    Release date:2026-03-13

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    This study first used transmission electron microscopy to demonstrate that the IFI27 protein is predominantly localized in the mitochondrial matrix. Subsequently, by generating gene-knockout mouse models and conducting a series of validation experiments, the researchers identified IFI27 as a novel regulator of mitochondrial metabolism and adaptive thermogenesis. On one hand, IFI27 specifically modulates the stability of SDHB in the mitochondrial matrix, thereby maintaining the normal function of succinate dehydrogenase; on the other hand, it interacts with the mitochondrial matrix protein HADHA, preserving its enzymatic activity and ensuring the proper functioning of the tricarboxylic acid cycle and fatty acid oxidation in brown adipose tissue (BAT)—the primary thermogenic organ—thus sustaining adaptive thermogenesis. In summary, this study elucidates the functional role of IFI27 in BAT and reveals its critical mechanisms in regulating mitochondrial metabolism and adapting to environmental changes.

    This study first used transmission electron microscopy to demonstrate that the IFI27 protein is predominantly localized in the mitochondrial matrix. Subsequently, by generating gene-knockout mouse models and conducting a series of validation experiments, the researchers identified IFI27 as a novel regulator of mitochondrial metabolism and adaptive thermogenesis. On one hand, IFI27 specifically modulates the stability of SDHB in the mitochondrial matrix, thereby maintaining the normal function of succinate dehydrogenase; on the other hand, it interacts with the mitochondrial matrix protein HADHA, preserving its enzymatic activity. This ensures the proper functioning of the tricarboxylic acid cycle and fatty acid oxidation in brown adipose tissue (BAT)—the primary thermogenic organ—thereby sustaining adaptive thermogenesis. In summary, this study elucidates the functional role of IFI27 in BAT and reveals its critical mechanisms in regulating mitochondrial metabolism and adapting to environmental changes.

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