FITC Mouse Anti-human CD3 Antibody (OKT3)
Application:
FC
Species reactivity:
Human
Host species:
Mouse
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Instruction manual- Product Description
- Composition
- Precautions
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Product Overview:
Product Name: FITC Mouse Anti-human CD3 Antibody (OKT3)
Antibody Type: Monoclonal
Validated Application: FC
Host: Mouse
Species Reactivity: Human
Conjugate: FITC
Clone: OKT3
Excitation/Emission: 498/526
Isotype: Mouse IgG2a, κProduct Overview:
The OKT3 monoclonal antibody specifically recognizes the CD3 epsilon subunit (CD3e/CD3ε) of the CD3 complex which consists of four transmembrane proteins (γ, δ, ε, ζ) that are associated with the T cell antigen
receptor (TCR) to form the CD3/TCR complex. The CD3 complex associates with either TCR αβ or TCR γδ heterodimers that are alternatively expressed by some thymocytes, T cells or NKT cells. The CD3 complex is
required for the cell surface expression and signal-transducing functions of the TCR. The CD3 complex is expressed by ~60-85% thymocytes and by all peripheral mature T cells.
CD3e is also known as T3E or TCRE. CD3e is a ~20 kDa unglycosylated type I transmembrane protein that is encoded by CD3E which belongs to the immunoglobulin superfamily (IgSF). CD3e has an Ig-like extracellular domain (ECD) and an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The OKT3 antibody can reportedly fix complement, stimulate T cell proliferation and cytokine production, and block the binding of other human CD3e-specific antibodies including UCHT1 and SK7.
FITC is designed to be excited by the Blue laser (488-nm) and detected using an optical filter centered near 520 nm (e.g., a 530/30-nm bandpass filter).Example Results:
As shown: Image of human PBMCs stained with FITC Mouse Anti-human CD3 Antibody, 5 µL/test.
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Product Composition:
Item number/specification Component Name Volume 11-1003-12 25T FITC Mouse Anti-human CD3 Antibody (OKT3) 125 μL 11-1003-15 100T FITC Mouse Anti-human CD3 Antibody (OKT3) 500 μL Storage: Store at 2–8°C, protected from light. Transport with ice packs.
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