FITC Mouse Anti-human CD8a Antibody (OKT8)
Application:
FC
Species reactivity:
Human
Host species:
Mouse
One-click copy of information
Instruction manual- Product Description
- Composition
- Precautions
-
Product Overview:
Product Name: FITC Mouse Anti-human CD8a Antibody (OKT8)
Antibody Type: Monoclonal
Validated Application: Flow Cytometry (FC)
Host: Mouse
Species Reactivity: Human
Conjugate: FITC
Clone: OKT8
Excitation/Emission (nm): 498/526
Isotype: Mouse IgG2a, κProduct Overview:
The OKT8 monoclonal antibody specifically recognizes CD8 alpha (CD8a or CD8α). CD8a is a ~32-34 kDa type I transmembrane glycoprotein that is encoded by CD8A, which belongs to the immunoglobulin superfamily (IgSF), and is commonly referred to as CD8. CD8a is expressed by the majority of thymocytes, subpopulations of αβ T cells and γδ T cells, and by subsets of NK cells. Cell surface CD8a is expressed either as a disulfide-linked homodimer (CD8αα) or as a heterodimer (CD8αβ) when disulfide-bonded to a CD8 beta chain (CD8b or CD8β). CD8-positive αβ T cells coexpress both CD8αα homodimers and CD8αβ heterodimers whereas some γδ T cells and NK cells express CD8αα homodimers. CD8 plays important roles in T cell activation and selection. The extracellular IgSF domain of CD8α binds to a non-polymorphic determinant on HLA class I molecules (α3 domain) and enables CD8 to function as a coreceptor with MHC class I-restricted TCR during T cell recognition of antigen. The cytoplasmic domain of CD8α associates with Lck, a Src family protein tyrosine kinase that is involved in intracellular signaling. The OKT8 antibody reportedly crossreacts with CD8a expressed by leucocytes from some non-human primate (NHP) species.
Other Names: T8, Leu2
Excitation Laser: Blue Laser (488 nm)Example Results:
FITC Mouse Anti-human CD8a Antibody staining of human PBMCs, 5 µL/test.
-
Product Composition:
Item number/specification Component Name Volume 11-1008-12 25T FITC Mouse Anti-human CD8a Antibody (OKT8) 125 μL 11-1008-15 100T FITC Mouse Anti-human CD8a Antibody (OKT8) 500 μL Storage: Store at 2–8°C, protected from light. Transport with ice packs.
Keywords
GOONIE
Product Recommendations
Content is being updated.
Submit your message
If you are interested in our products, please provide your email address, and we will contact you as soon as possible. Thank you!
Goonie Biotechnology (Guangzhou) Co., Ltd.
Room 321–332, Building G5, No. 39 Ruihe Road, Huangpu District, Guangzhou
Customer Service QR Code
Friendly Links
