FITC Rat Anti-mouse F4/80 Antibody (A3-1)
Application:
FC, IF
Species reactivity:
Mouse
Host species:
Rat
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Instruction manual- Product Description
- Composition
- Precautions
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Product Overview:
Product Name: FITC Rat Anti-mouse F4/80 Antibody (A3-1)
Antibody Type: Monoclonal
Validated Applications: FC, IF
Host: Rat
Species Reactivity: Mouse
Conjugate: FITC
Clone: A3-1
Excitation/Emission: 498/526
Isotype: Rat IgG2b, kappaProduct Overview:
The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells,
Langerhans cells, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus,
bone marrow stroma and macrophages in the red pulp of the spleen (Hume, et al. 1984). F4/80 antigen is
also expressed on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of
the spleen and lymph node (Gordon, et al. 1994). The ligands and biological functions of the F4/80 antigen
have not been fully determined but a role for F4/80 in the generation of efferent CD8+ve regulatory T cells is
proposed (Lin, et al. 2005). Rat anti mouse F4/80 antibody, clone Cl:A3-1 modulates cytokine levels
released in response to Listeria monocytogenes (Warschkau & Kiderlen, 1999).
Swiss Prot: P48455
Other Names: EMR1, Ly71
Excitation Laser: Blue Laser (488 nm) -
Product Composition:
Item number/specification Component Name Volume 11-27001-12 25T FITC Rat Anti-mouse F4/80 Antibody (A3-1) 125 μL 11-27001-15 100T FITC Rat Anti-mouse F4/80 Antibody (A3-1) 500 μL Storage: Store at 2–8°C, protected from light. Transport with ice packs.
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