PE Mouse Anti-human CD8a Antibody (OKT8)
Application:
FC
Species reactivity:
Human
Host species:
Mouse
One-click copy of information
Instruction manual- Product Description
- Composition
- Precautions
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产品概述:
产品名称：PE Mouse Anti-human CD8a Antibody (OKT8)
抗体类型：Monoclonal
验证应用：FC
宿主：Mouse
种属反应性：Human
偶联物：PE
克隆号：OKT8
激发光/发射光：565/574
亚型：Mouse IgG2a, κ产品背景:
The OKT8 monoclonal antibody specifically recognizes CD8 alpha (CD8a or CD8α). CD8a is a ~32-34 kDa
type I transmembrane glycoprotein that is encoded by CD8A, which belongs to the immunoglobulin
superfamily (IgSF), and is commonly referred to as CD8.
CD8a is expressed by the majority of thymocytes, subpopulations of αβ T cells and γδ T cells, and by subsets
of NK cells. Cell surface CD8a is expressed either as a disulfide-linked homodimer (CD8αα) or as a
heterodimer (CD8αβ) when disulfide-bonded to a CD8 beta chain (CD8b or CD8β). CD8-positive αβ T cells
coexpress both CD8αα homodimers and CD8αβ heterodimers whereas some γδ T cells and NK cells express
CD8αα homodimers. CD8 plays important roles in T cell activation and selection. The extracellular IgSF
domain of CD8α binds to a non-polymorphic determinant on HLA class I molecules (α3 domain) and enables
CD8 to function as a coreceptor with MHC class I-restricted TCR during T cell recognition of antigen. The
cytoplasmic domain of CD8α associates with Lck, a Src family protein tyrosine kinase that is involved in
intracellular signaling. The OKT8 antibody reportedly crossreacts with CD8a expressed by leucocytes from
some non-human primate (NHP) species.
Other Names: T8, Leu2
Excitation Laser: Blue (488 nm), Green (532 nm) and Yellow-Green (561 nm) laser.结果示例：
如图： PE Mouse Anti-human CD8a Antibody染色人PBMC结果，5µL/test.
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Product Composition:
Item number/specification Component Name Volume 12-1008-12 25T PE Mouse Anti-human CD8a Antibody (OKT8) 125 μL 12-1008--15 100T PE Mouse Anti-human CD8a Antibody (OKT8) 500 μL Storage: Store at 2–8°C, protected from light. Transport with ice packs.
Keywords
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