AF647 Mouse Anti-human CD8a Antibody (OKT8)
Application:
FC
Species reactivity:
Human
Host species:
Mouse
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Instruction manual- Product Description
- Composition
- Precautions
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产品概述:
产品名称：AF647 Mouse Anti-human CD8a Antibody (OKT8)
抗体类型：Monoclonal
验证应用：FC
宿主：Mouse
种属反应性：Human
偶联物：AF647
克隆号：OKT8
激发光/发射光：648/664
亚型：Mouse IgG2a, κ产品背景：
The OKT8 monoclonal antibody specifically recognizes CD8 alpha (CD8a or CD8α). CD8a is a ~32-34 kDa type I transmembrane glycoprotein that is encoded by CD8A, which belongs to the immunoglobulin superfamily (IgSF), and is commonly referred to as CD8.
CD8a is expressed by the majority of thymocytes, subpopulations of αβ T cells and γδ T cells, and by subsets of NK cells. Cell surface CD8a is expressed either as a disulfide-linked homodimer (CD8αα) or as a heterodimer (CD8αβ) when disulfide-bonded to a CD8 beta chain (CD8b or CD8β). CD8-positive αβ T cells coexpress both CD8αα homodimers and CD8αβ heterodimers whereas some γδ T cells and NK cells express CD8αα homodimers. CD8 plays important roles in T cell activation and selection. The extracellular IgSF domain of CD8α binds to a non-polymorphic determinant on HLA class I molecules (α3 domain) and enables CD8 to function as a coreceptor with MHC class I-restricted TCR during T cell recognition of antigen. The cytoplasmic domain of CD8α associates with Lck, a Src family protein tyrosine kinase that is involved in intracellular signaling. The OKT8 antibody reportedly crossreacts with CD8a expressed by leucocytes from some non-human primate (NHP) species.
Other Names: T8, Leu2
Excitation Laser: Red laser (633-nm). -
Product Composition:
Item number/specification Component Name Volume 26-1008-12 25T AF647 Mouse Anti-human CD8a Antibody (OKT8) 125 μL 26-1008-15 100T AF647 Mouse Anti-human CD8a Antibody (OKT8) 500 μL Storage: Store at 2–8°C, protected from light. Transport with ice packs.
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GOONIE
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